Barrett´s esophagus – a review. Esofago de Barrett. C. Ciriza-de-los-Ríos. Service of Digestive Diseases. Hospital Universitario “12 de Octubre”. Madrid, Spain. Servicio de Gastroenterología. Hospital Universitario Ramón y Cajal. Esófago de Barrett. Barrett´s esophagus. El esófago de Barrett (EB) es una consecuencia a. El esófago de Barrett es una condición en la cual se daña el revestimiento del esófago. El esófago es el tubo que lleva los alimentos desde la boca hasta.

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Advances in molecular biology have allowed the detection of abnormal expression in various genes that correlate with the transition from normal esophagus to ADC Another eosfago with endoscopies on patients with various indications found that the esophageal squamous mucosa merges with the gastric oxyntic mucosa in Human model of duodenogastro-oesophageal reflux in the development of Barrett’s metaplasia.

Once esophageal metaplasia develops BE length does not considerably change over time Later stages of adenocarcinoma may be treated with surgical resection or palliation.

The action of acid and pepsin weakens cell junctions and widens intracellular gaps, thus letting acid in. Secondary chemoprevention of Barrett’s esophagus with celecoxib: Diagnosis As suggested in the definition, regardless of which one is considered, a diagnosis with BE requires the identification of gastric metaplasia cylindrical epithelium in endoscopy, and its histological confirmation.

Fundoplication seems better than PPI therapy in observational studies regarding the incidence of ADC, but controlled studies find no differences Endoscopic ablation of Barrett’s esophagus: Cyclooxygenase 2 expression in Barrett’s esophagus and adenocarcinoma: Loss of nuclear polarity strongly suggests dysplasia. Mucosal damage stenosis and ulceration is a risk factor for ADC Gastro-oesophageal reflux associated with nocturnal gastric acid breakthrough on proton pump inhibitors.

Other promising techniques include Fuji intelligent color chromoendoscopy FICEoptical coherence tomography systems OCTand autofluorescence, with consensus that further validation and effectiveness assessment are needed before they can be implemented or recommended on a general basis.


Current recommendations include routine endoscopy and biopsy looking for dysplastic changes. Surveillance of Barrett’s oesophagus: A further association was made with adenocarcinoma in Laparoscopic treatment of Barrett’s esophagus: In this sense Vieth et al. Previous studies defined a normal Z line as the junction between esophageal squamous epithelium and cardial epithelium.

These compounds are inert with neutral pH but become oxidative compounds with acid pH that may have mutagenic potential. Hum Pathol ; D ICD – Interestingly, despite its purely speculative character, this description would become dogma for over 30 years 1. Regardless of the chosen protocol, biopsies should be collected from the most proximal columnar metaplastic area when diagnosing intestinal metaplasia It is important that the endoscopic diagnosis of BE be standardized.

When severe it may have a polypoid appearance Service of Digestive Diseases. Studies with a long follow-up are needed to confirm that BE clearance is sustained over time. Previous studies such as the one by Csendes et al. Br J Surg ; There is no anatomical structure unequivocally separating the esophageal end from the beginning of the stomach.

Esofago de Barrett

The squamous-columnar junction or Z line macroscopically corresponds to an obvious, regular or irregular, circumferential colour change at the distal esophagus, which results from the border between the flat esophageal mucosa and the columnar gastric mucosa.

GEJ proximal of gastric foldssquamous-columnar junction Z lineand hiatal imprint. Am J Gastroenterol ; A normal endoscopic exam may also ensue, and the condition is only detectable with biopsies immediately esogago to the squamous epithelium.

Colonic metaplasia is usually identified by finding goblet cells in the epithelium and is necessary for the true diagnosis. Studies using high-resolution esophageal manometry suggests that in patients with reflux, even in the absence of HH, there is separation between both sphincters BE description including limits both nearest and farthest regarding GEJ is a reasonable approach to quantify extension. A critical review of the diagnosis and management of Barrett’s esophagus: There is some debate on the need for aggressive antireflux therapy in all patients with BE regardless of reflux severity.


The presence of molecular markers biomarkers to select groups at risk of developing HGD or ADC, has increased the efficacy and cost-effectiveness of endoscopic surveillance. Location of the lower oesophageal sphincter and the squamous columnar mucosal junction in healthy controls and patients with barrt degrees of endoscopic oesophagitis. Seminars in Radiation Oncology.

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From an endoscopic point of view structures such as the vascular palisade or eosfago narrowing have been described, but there is currently consensus that the best endoscopic description of GEJ is defined by the proximal limit of gastric folds during partial insufflation The development and validation of an endoscopic grading system for Barrett’s esophagus: Retrieved 28 July The incidence of ADC has progressively increased whereas the incidence of squamous-cell carcinoma has declined.

Three patterns have been described for chromoendoscopy with Indigo carmine: Wikimedia Commons has media related to Barrett’s esophagus. Helicobacter pylori does not seem to play a role in BE; Helicobacter pylori strains expressing cytokine associated to gene A cagA may even be a potential protective factor in decreasing acid production because of secondary gastritis 43, Vital staining with Methylene blue seems less sensitive than Seattle protocol to detect dysplasia Mod Pathol ;